The slightest bitThe answer is A tad.
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Nature, Published online: 25 February 2026; doi:10.1038/d41586-026-00515-x
Benchmarking this is tricky, but we ran an experiment in 2020 to precisely measure the overhead that JS glue code has in a real world DOM application. We built the classic TodoMVC benchmark in the experimental Dodrio Rust framework and measured different ways of calling DOM APIs.